Archive for Urology News

Cancer Biomarkers Missing in Action (CME/CE)

(MedPage Today) — Biomarkers for cancer — often reported with great publicity — routinely fail to be of clinical use, a Canadian researcher said.

FDA Dings Prostate CA Drugmaker on Marketing

(MedPage Today) — The maker of the prostate cancer immunotherapy sipuleucel-T (Provenge) has exaggerated the therapy’s efficacy and played down its risks in some marketing materials, the FDA charged.

Supplement Scrutinized for Arrhythmia Risk (CME/CE)

(MedPage Today) — Men taking a dietary supplement marketed as a sexual function aid had a significant increase in cardiac QTc interval that persisted for five hours after a single dose, a small study of healthy volunteers showed.

Comorbidities May Be Key in Prostate Cancer Tx Decisions (CME/CE)

(MedPage Today) — A questionnaire for men with prostate cancer that evaluates comorbidities may help in clinical decision-making about treatment by estimating their likelihood of dying from other conditions, researchers found.

Little Interest in Drug to Prevent Prostate Cancer (CME/CE, with audio)

(MedPage Today) — Physicians continue to shy away from prescribing finasteride to prevent prostate cancer, despite evidence from a large clinical trial showing that the drug significantly reduced the risk, a survey showed.

Bone Density May Predict Prostate Cancer in Old Age (CME/CE)

(MedPage Today) — Bone scans might help identify men at high risk for aggressive prostate tumors as they age, researchers said.

PSA Screening Can Lead to Overtreatment (CME/CE, with video)

Many men being treated aggressively for low-grade prostate cancer (MedPage Today) — particularly if it was detected during prostate-specific antigen screening — are unlikely to benefit from the intervention, a new study suggests.

PSA Screening Can Lead to Overtreatment (CME/CE)

Many men being treated aggressively for low-grade prostate cancer (MedPage Today) — particularly if it was detected during prostate-specific antigen screening — are unlikely to benefit from the intervention, a new study suggests.

Gene Therapy Benefits Persist in SCID (CME/CE)

Gene therapy appears to have long-term success for treating X-linked severe combined immunodeficiency disease (SCID) (MedPage Today) — but recipients are at risk for acute leukemia, according to a small study from France.

Paint May Hike Bladder Cancer Risk (CME/CE)

People exposed to paint on the job (MedPage Today) — including painters plasterers, artists, decorators, and other workers — appear to have an increased risk of bladder cancer, a meta-analysis showed.

Impotence Drug Use, STDs Linked (CME/CE)

A major retrospective study showed that men prescribed erectile dysfunction (ED) drugs such as sildenafil (Viagra) also had markedly higher rates of sexually transmitted diseases (MedPage Today) — though the association could have more to do with behavior than ED drug use.

CMS Considers Payment Policy for Provenge

WASHINGTON (MedPage Today) — The Centers for Medicare and Medicaid Services announced it has started the process of deciding whether to cover the costly prostate cancer immunotherapeutic agent sipuleucel-T (Provenge).

Testosterone Gel Linked to Risk of MI and Stroke (CME/CE)

Applying topical testosterone appears to raise the risk of cardiovascular events including myocardial infarction, atrial fibrillation, and stroke in older men with limited mobility, a study has found.

Swedish Study Adds Fuel to PSA Screening Debate (CME/CE)

Screening based on prostate-specific antigen (PSA) dramatically reduced mortality from prostate cancer in a large 14-year randomized trial in Swedish men, researchers said.

Statins Reduce PSA Spikes After Prostatectomy (CME/CE)

Among men who underwent radical prostatectomy, biochemical recurrence (MedPage Today) — a spike in prostate specific antigen (PSA) over a critical threshold — was less likely in men on statin therapy, a retrospective study showed.

ASMBS: Women’s Sex Life Better After Bariatric Surgery (CME/CE)

LAS VEGAS (MedPage Today) — Sexual function improved in almost 70% of obese women who underwent bariatric surgery, according to data from a small prospective cohort study.

Outlawed Insecticide Linked to Prostate Cancer (CME/CE)

Exposure to the long-banned organochloride insecticide chlordecone may be associated with a greater chance of developing prostate cancer, a new case-control study showed.

Is single-dose postoperative intravesical gemcitabine effective to prevent recurrence in patients with non-muscle invasive bladder cancer?

Jain Abhishek, Goel Apul, Sankhwar S N

Indian Journal of Urology 2010 26(1):153-155

Best Reviewers, 2009

Indian Journal of Urology 2010 26(1):156-156

Antifracture agents for prostate cancer patients on androgen deprivation therapy

Singh Bhupendra P, Goel Apul, Gupta Ankush

Indian Journal of Urology 2010 26(1):149-150

Optimizing the adjuvant therapy in stage I nonseminomatous germ cell tumors

Singh Bhupendra P, Choubey Vimal K, Pandey Rahul

Indian Journal of Urology 2010 26(1):150-152

Intermittent androgen deprivation for locally advanced and metastatic prostate cancer: Where is the evidence?

Nirmal T J, Kumar S

Indian Journal of Urology 2010 26(1):152-153

Small incision basilic vein transposition technique: A good alternative to standard method

Veeramani Muthu, Vyas Jigish, Sabnis Ravindra, Desai Mahesh

Indian Journal of Urology 2010 26(1):145-147

End-stage renal disease is a significant health problem. The primary use of the autogenous arteriovenous access is recommended by NKF-DOQI (National Kidney Foundation-Dialysis Outcomes Quality Initiative) guidelines. Though basilic vein transposition is well established in multiple failed fistulae's and obese patients, it requires large incision and morbidities like edema and infection. To avoid such compilations we, at our institution, adopted a small incision technique using two small 3-4 cm incisions. This method is inspired by videoendoscopic minimally invasive method used to dissect the basilic vein, thus avoiding extensive dissection and related morbidities.

Tamsulosin for distal ureteric calculus: Does it deliver the goods?

Nirmal T J, Kekre Nitin S

Indian Journal of Urology 2010 26(1):148-149

Maximal androgen blockade for advanced prostate cancer

Mukha Rajiv Paul, Kumar Santosh, Kekre N S

Indian Journal of Urology 2010 26(1):133-138

Prostate cancer has now become one of the leading types of cancer in urban India. It is now the third most common cancer in Delhi. As we advance in health care with the resultant increase in longevity, we will be seeing more of advanced carcinoma prostate. Since the early 1980.s, there have been many trials on MAB. However, the question remains whether these agents actually make a difference? The role of MAB is probably limited to the prevention of the ß are reaction in patients on LHRH agonists. The non steroidal antiandrogens have a marginal benefit of increased overall survival by approximately 3% to 5% at 5 ve years. There may be a role for MAB in patients with metastatic carcinoma of prostate, low volume metastases, patients with M 1 disease with absence of metastases in the skull, ribs, long bones, and soft tissues excluding lymph nodes.

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